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Propecia ( finasteride ), a synthetic 4-azasteroid compound,
is a specific inhibitor of steroid Type II 5a-reductase, an
intracellular enzyme that converts the androgen testosterone
into 5a-dihydrotestosterone ( DHT ).
Finasteride is 4-azaandrost-1-ene-17-carboxamide,N-(
1,1-dimethylethyl ) - 3-oxo-,( 5a,17b ) -. The empirical formula
of finasteride is C23H36N2O2
and its molecular weight is 372.55. Its structural formula
is:
Finasteride is a white crystalline powder with a melting point
near 250°C. It is freely soluble in chloroform and in lower
alcohol solvents but is practically insoluble in water.
PROPECIA tablets for oral administration are film-coated tablets
that contain 1 mg of finasteride and the following inactive
ingredients: lactose monohydrate, microcrystalline cellulose,
pregelatinized starch, sodium starch glycolate, docusate sodium,
magnesium stearate, hydroxypropyl methylcellulose 2910, hydroxypropyl
cellulose, titanium dioxide, talc, yellow ferric oxide, and
red ferric oxide.
Clinical Pharmacology - Introduction
Clinical
Pharmacology - Pharmacokinetics
Clinical
Pharmacology - Clinical Studies
Indications
and Usage
Contraindications
Warnings
Precautions
Adverse Reactions
Overdosage
Dosage and Administration
How Supplied
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